Tecovirimat (TPOXX): Information for the Public

Tecovirimat (TPOXX): Information for the Public

Most people do not require treatment for monkeypox. For severe cases that require treatment, Tecovirimat (TPOXX) was developed to protect against smallpox and may be used to treat monkeypox. Tecovirimat (TPOXX), is recommended for people who are more likely to get severely ill — for example — patients with weakened immune systems or severe disease.

The CDC, in partnership with the FDA, has made it easier for patients to receive Tecovirimat (TPOXX) treatment for monkeypox under an expanded access Investigational New Drug (EA-IND) protocol (also known as compassionate use). For additional information about Tecovirimat visit https://www.cdc.gov/poxvirus/monkeypox/pdf/Written-Summary.pdf

Tecovirimat (TPOXX) is available both as a pill or as an intravenous (IV) infusion. IV Tecovirimat is only given when an individual cannot tolerate taking oral medication.

Tecovirimat is given as a 14-day course and should be taken 30 minutes after eating a full, fatty meal. Take each dose with a full glass of water. The meal should contain about 600 calories and 25 grams of fat. Examples might include: cheeseburger with fries, rice with fried chicken, pasta alfredo, bagel with cream cheese, avocado, peanut butter, ready-to-drink meal, etc.

People who have severe infection should seek medical care and speak with their provider about receiving Tecovirimat.