Human papillomavirus (HPV) is a virus passed from one person to another during skin-to-skin sexual contact, including vaginal, oral, and anal sex. HPV can be spread even when an infected person has no signs or symptoms. It is the most common of sexually transmitted diseases, and anyone who has had sex can get HPV. Most infections never develop symptoms or health problems. There are rare cases of HPV developing into more serious health problems, including cancer.